12:00 pm - 1:45 pm
 | Roundtable Discussion #9
Credit Hours:1.75 CME/CMLE
The Impact of Changing Clinical Practice Patterns and Guidelines on Gynecologic Cytopathology
Armanda Tatsas, MD
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Educational Objectives:
1. Review the latest clinical guidelines for cervical cancer screening as published by various professional and governmental organizations, including the American Society for Colposcopy and Cervical Pathology, and United States Preventative Services Task Force
2. Examine how changing practice patterns impact the workflow in the cytopathology laboratory
3. Understand how changes in workflow impact specimen triage, turnaround time, and quality assurance/improvement measures
4. Discuss individual laboratory experience with clinician adherence to the guidelines and ways to increase collaboration with clinical colleagues in order to improve patient care
Clinical guidelines and practice recommendations for cervical cancer screening and management of abnormal tests impact the volume of gynecologic cytopathology specimens submitted to the cytopathology laboratory. In addition, changing practice guidelines place increased emphasis on ancillary testing including high-risk HPV detection and genotyping. An understanding of the latest clinical guidelines is essential for cytotechnologists and cytopathologists to handle the shifting workflow while maintaining high quality practices in the laboratory.
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12:00 pm - 1:45 pm

 | Roundtable Discussion #10
Credit Hours:1.75CME/CMLE
Starting Up an On-Site Adequacy Service
Deborah Chute, MD
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Educational Objectives:
1. Understand the administrative challenges of starting an on-site adequacy service
2. Be able to discuss the technical aspects of starting an on-site adequacy service, including the use of real-time web-based video microscopy
3. Discuss the potential role of cytotechnologists in starting and continuing an on-site adequacy service
In many fields of clinical medicine, the ability of cytology adequacy assessments to improve diagnostic rates and decrease repeat procedures has been well documented. Radiologists, gastroenterologists, endocrinologists, surgeons and oncologists are increasingly requesting our services in this manner. In addition, what has largely been restricted to large academic centers is now expanding into private practice hospitals. Traditionally, many cytopathology practices have not had on-site adequacy techniques available, but are considering adding this valuable service. This session will address the administrative, technical, and personnel challenges and choices that make starting a new on-site adequacy service appear overwhelming. The presenter will draw upon their previous experience with rapid assessment services. New technologies, including implementation of web-based cameras for beaming images across hospitals will be discussed. And finally, the role cytotechnologists in the development and implementation of an on-site adequacy service will be discussed. By the end of the presentation, the attendees will have the information and tools needed to start an adequacy service at their institution.
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12:00 pm - 1:45 pm
  | Roundtable Discussion #11
Credit Hours:1.75 CME/CMLE
The Bethesda System for Thyroid FNA: Can We Minimize Significant Discrepancies on Second Opinions?
Nora J. Morgenstern, MD
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Educational Objectives:
1. To raise awareness of interobserver variability for morphologic criteria used to classify Thryoid FNAs into Diagnostic Categories according to the Bethesda System
2. To discuss application of criteria in an attempt to standardize interpretation for each of the diagnostic categories
3. To agree on helpful boundaries for each of the diagnostic categories (quantity and quality)
4. To discuss pros and cons of comments and recommendations used in Thyroid FNA reports
The National Cancer Institute (NCI) sponsored the NCI Thyroid Fine-needle Aspiration (FNA) State of the Science Conference in October, 2007 in Bethesda, MD. The proposed Bethesda System for Thyroid FNA interpretation and reporting is subject to Interobserver Variability. Discrepancy in Thyroid FNA second opinions varies among institutions and can result in significant changes for patient management. Review of proposed morphologic criteria for each category of the Bethesda System for Thyroid FNA and discussion of quantity and quality for each of these criteria may help raise awareness of how to optimize the use of diagnostic categories when differences in management are significant. Taking into account clinical, sonographic, nuclear medicine and molecular findings, when available, can better serve as the "triple test" when evaluating difficult cases.
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12:00 pm - 1:45 pm

 | Roundtable Discussion #12
Credit Hours:1.75 CME/CMLE
Transformation of Cytology Practice - The Mayo Clinic Experience
Amy C. Clayton, MD
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Educational Objectives:
1. Understand how the unique skills of the cytotechnologist make them ideal candidates for expanded roles in the anatomic pathology practice
2. Identify specific areas of expanded responsibilities that add value to laboratory services and sustain profession viability
3. Understand work flow processes using the cytotechnologist in expanded roles that help create efficiency in the practice setting
Specific practice changes detailing the expanded roles of cytotechnologists in Mayo Clinic Anatomic Pathology will be presented. The changes include molecular testing (FISH), expanded morphology evaluation (image analysis, quantitative immunohistochemical stain preview and tumor identification for molecular testing) and new technologies (circulating tumor cell analysis).
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12:00 pm - 1:45 pm

 | Roundtable Discussion #13
Credit Hours:1.75 CME/CMLE
Reducing Atypical Cytology with Molecular Approaches
Bin Yang, MD, PhD
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Educational Objectives:
1. Understand the role of molecular cytopathology in present and future cytology practice
2. Provide audiences the challenge and opportunity for exploring molecular tests while focusing on tackling atypical cytology
There is overlapping features between benign and malignancy cytologically in many situations. Thus far “atypical cytology” has become the acceptable term in practice. Atypical cytology did not meet needs sometimes for clinical management decision making. Reducing atypical diagnosis in cytology will not only improve our professional reputation but more importantly, provide better evidence for patient care. Cytologic materials are suitable for molecular studies. Using molecular approaches to detect some intrinsic alterations in cancer cells will help us render more accurate cytologic diagnosis in addition to cytomorphology. Through this lecture we hope audiences will have a flavor of the present and future of molecular cytopathology.
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12:00 pm - 1:45 pm
 | Roundtable Discussion #14
Credit Hours:1.75 CME/CMLE
Current State of Personalized Medicine in Lung Carcinoma: Essentials of Cytologic Approach for the Pathologist and Cytotechnologist
Peter Kulesza, MD, PhD(ASCP)
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Educational Objectives:
1. Describe the molecular aberrations in specific histologic subtypes of Non–small cell lung cancer (NSCLC)
2. Describe the analytical methods used to detect the molecular phenotype(s), and apply that knowledge to appropriate specimen types to avoid erroneous assay results
Non–small cell lung cancer (NSCLC) is traditionally classified by histology, but until recently, histologic subtype has had little impact on the selection of therapy. Drugs such as pemetrexed and bevacizumab are indicated for specific NSCLC subtypes, and this type of stratification represents the first step toward individualizing therapy in NSCLC. Beyond histology, the status of molecular targets, such as the epidermal growth factor receptor (EGFR) gene, has been shown to correlate with response to treatment with EGFR tyrosine kinase inhibitors (TKIs) in patients with relapsed/refractory disease as well as in the first-line setting. New therapies targeting the EGFR and other molecular aberrations are under way to help define specific subsets of patients responsive to certain molecularly targeted treatments. The role of the pathologist in guiding treatment decisions will increase because molecular profiling, together with pathologic and histologic analysis, represents the future of personalizing medicine for patients with NSCLC.
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12:00 pm - 1:45 pm
 | Roundtable Discussion #15
Credit Hours:1.75 CME/CMLE
Using Innovation and Informatics in Today’s Cytopathology QA: Practical Measures to Improve the Process and Its Yield for Your Laboratory
Robert A. Goulart, MD
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Educational Objectives:
1. Appreciate the emerging role of informatics in cytology QA
2. Gain insight into how informatics can allow innovation in the QA process and how to facilitate these ideas through collaboration with our allied health care colleagues
3. Better utilize reporting systems, monitors and indicators in the laboratory
4. Expand your QA processes to gain educational feedback for your residency and fellowship programs, with demonstration of graduated competency
Automation and emerging information technologies (IT) are being increasingly adopted in cytopathology to augment Pap test screening, improve diagnostic accuracy and facilitate the quality assurance process. Laboratory informatics, the application of computers and information systems to information management in the pathology laboratory, has now become an essential component in the field of cytopathology. Providing information in a manner that is most effective for patient care is the primary mission of the cytology laboratory, and informatics is our latest, greatest tool to help us realize this goal. The application of informatics to the QA process can not only facilitate standard and federally required QA indicators, but can also allow for the monitoring of innovative measures which better reflect your laboratory practice and offer more meaningful feedback. Collaborative opportunities with our allied health care colleagues (IT specialists, residency/fellowship program directors and administrators) will be presented. This discussion will further demonstrate how informatics can be specifically used to make your QA process work faster, easier, and smarter, while allowing for creative and clinically useful monitoring beyond CLIA for your cytotechnologists, residents, fellows, and patients.
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12:00 pm - 1:45 pm
 | Roundtable Discussion #16
Credit Hours:1.75 CME/CMLE
Asking “Why?” – Getting to the Root Cause and the Right Solution to Problems in the Cytopathology Laboratory
Kalyani Naik, MS, SCT(ASCP)
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Educational Objectives:
1. Explain the role of asking “why” in problem solving and continuous quality improvement
2. Identify lean tools that can be used for effective problem solving
3. Apply lean tools to identify root cause(s) and develop solutions to “real-life” problems that may be encountered in cytopathology laboratory
Problems, even in the highest quality laboratories, are inevitable. Identification of these problems, their true, or root causes and the most effective solutions are essential to any continuous quality improvement plan. Jumping to solutions that address only the symptom is human nature; determining the right solutions that actually prevent the problem from recurring and result in true, sustained improvement is more challenging. One of the keys to effective problem solving is to find the right solution by taking the time to thoroughly understand the problem and ask “why” until the root cause is discovered. Problem solving is an integral component of lean, a quality management system that has been implemented in many areas of medicine, including laboratory medicine, as a means of achieving continuous improvement. This roundtable discussion will give an overview of lean principles as they relate to the successful implementation of tools that facilitate effective problem solving and continuous improvement. Specific problem-solving lean tools, such as the A3, 5-why’s, and fishbone analysis, will be shared. Participants will have the opportunity to apply these tools in order to demonstrate how they can be utilized to analyze “real life” problems that may be encountered in the cytopathology laboratory, identify their root causes and develop effective solutions.
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